Regression of Microalbuminuria in Type 1 Diabetes

作者: Bruce A. Perkins , Linda H. Ficociello , Kristen H. Silva , Dianne M. Finkelstein , James H. Warram

DOI: 10.1056/NEJMOA021835

关键词: MicroalbuminuriaProspective cohort studyEndocrinologyType 1 diabetesUrologyProteinuriaExcretionConfidence intervalInternal medicineCumulative incidenceMedicineAlbuminuria

摘要: Background In the present study, we aimed to determine frequency of a significant reduction in urinary albumin excretion and factors affecting such patients with type 1 diabetes microalbuminuria. Methods The study included 386 persistent microalbuminuria, indicated by repeated measurements (estimated on basis albumin-to-creatinine ratios) range 30 299 μg per minute during an initial two-year evaluation period. Subsequent next six years were grouped into periods, averaged, analyzed for regression which was defined as 50 percent from one period next. Results Regression microalbuminuria frequent, six-year cumulative incidence 58 (95 confidence interval, 52 64 percent). use angiotensin-converting–enzyme inhibitors not associated microalbuminuria...

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