Cardinal Role of the Intrarenal Renin-Angiotensin System in the Pathogenesis of Diabetic Nephropathy
作者： Hiroyuki Kobori , Masumi Kamiyama , Lisa M. Harrison-Bernard , L. Gabriel Navar
DOI: 10.2310/JIM.0B013E31827C28BB
关键词:
摘要: Diabetes mellitus is one of the most prevalent diseases and associated with increased incidence structural functional derangements in kidneys, eventually leading to end-stage renal disease a significant fraction afflicted individuals. The renoprotective effects renin-angiotensin system (RAS) blockade have been established; however, mechanistic pathways not fully elucidated. In this review article, cardinal role an activated RAS pathogenesis diabetic nephropathy (DN) discussed focus on 4 themes: (1) introduction cascade, (2) intrarenal diabetes, (3) clinical outcomes DN, (4) potential urinary angiotensinogen as early biomarker status DN. This article provides rational supporting hypothesis that contributes DN levels provide index activity.
sci-hub.se 参考文章(105)
Sungmi Park, Benjamin J. Bivona, Hiroyuki Kobori, Dale M. Seth, Mark C. Chappell, Eric Lazartigues, Lisa M. Harrison-Bernard, Major role for ACE-independent intrarenal ANG II formation in type II diabetes. American Journal of Physiology-renal Physiology. ,vol. 298, ,(2010) , 10.1152/AJPRENAL.00519.2009
Navar Lg, Kobori H, Harrison-Bernard Lm, Expression of Angiotensinogen mRNA and Protein in Angiotensin II-Dependent Hypertension Journal of The American Society of Nephrology. ,vol. 12, pp. 431- 439 ,(2001) , 10.1681/ASN.V123431
Hiroyuki Kobori, Masaomi Nangaku, L. Gabriel Navar, Akira Nishiyama, The Intrarenal Renin-Angiotensin System: From Physiology to the Pathobiology of Hypertension and Kidney Disease Pharmacological Reviews. ,vol. 59, pp. 251- 287 ,(2007) , 10.1124/PR.59.3.3
L. Gabriel Navar, Lisa M. Harrison-Bernard, Akira Nishiyama, Hiroyuki Kobori, Regulation of Intrarenal Angiotensin II in Hypertension Hypertension. ,vol. 39, pp. 316- 322 ,(2002) , 10.1161/HY0202.103821
Tatsuo Yamamoto, Tsutomu Nakagawa, Hiroyuki Suzuki, Naro Ohashi, Hirotaka Fukasawa, Yoshihide Fujigaki, Akihiko Kato, Yukio Nakamura, Fumiaki Suzuki, Akira Hishida, Urinary angiotensinogen as a marker of intrarenal angiotensin II activity associated with deterioration of renal function in patients with chronic kidney disease Journal of The American Society of Nephrology. ,vol. 18, pp. 1558- 1565 ,(2007) , 10.1681/ASN.2006060554
Yan Yan Zhao, Jie Zhou, Chittampalli S. Narayanan, Yanning Cui, Ashok Kumar, Role of C/A Polymorphism at −20 on the Expression of Human Angiotensinogen Gene Hypertension. ,vol. 33, pp. 108- 115 ,(1999) , 10.1161/01.HYP.33.1.108
S. Anderson, F. F. Jung, J. R. Ingelfinger, Renal renin-angiotensin system in diabetes: Functional, immunohistochemical, and molecular biological correlations American Journal of Physiology-renal Physiology. ,vol. 265, ,(1993) , 10.1152/AJPRENAL.1993.265.4.F477
Yukiko Nagai, Li Yao, Hiroyuki Kobori, Kayoko Miyata, Yuri Ozawa, Akira Miyatake, Tokihito Yukimura, Takatomi Shokoji, Shoji Kimura, Hideyasu Kiyomoto, Masakazu Kohno, Youichi Abe, Akira Nishiyama, Temporary Angiotensin II Blockade at the Prediabetic Stage Attenuates the Development of Renal Injury in Type 2 Diabetic Rats Journal of The American Society of Nephrology. ,vol. 16, pp. 703- 711 ,(2005) , 10.1681/ASN.2004080649
Julie L. Lavoie, Kristy D. Lake-Bruse, Curt D. Sigmund, Increased blood pressure in transgenic mice expressing both human renin and angiotensinogen in the renal proximal tubule American Journal of Physiology-renal Physiology. ,vol. 286, pp. 965- 971 ,(2004) , 10.1152/AJPRENAL.00402.2003
Allan R. Brasier, Junyi Li, Mechanisms for Inducible Control of Angiotensinogen Gene Transcription Hypertension. ,vol. 27, pp. 465- 475 ,(1996) , 10.1161/01.HYP.27.3.465