Comparison of intrarenal renin-angiotensin system activity in diabetic versus non-diabetic patients with overt proteinuria
作者： Ji Hyeon Park , Hye Ryoun Jang , Jong-Ho Lee , Jung Eun Lee , Wooseong Huh
DOI: 10.1111/NEP.12383
关键词: Renal function 、 Renin–angiotensin system 、 Urinary system 、 Diabetes mellitus 、 Endocrinology 、 Nephropathy 、 Creatinine 、 Internal medicine 、 Diabetic nephropathy 、 Urology 、 Proteinuria 、 Medicine
摘要: Aim The intrarenal renin-angiotensin system (RAS) has been reported to be activated in chronic proteinuria patients. This study aimed compare RAS activity between diabetic nephropathy (DN) and non-diabetic (NDN) patients with overt proteinuria. Methods A multicenter, cross-sectional was conducted 116 (urinary protein/creatinine ratio [uPCR] > 1 mg/mg Cr). To estimate we measured urinary excretion of angiotensinogen (uAGT) renin (uRenin) DN (n = 38) NDN (n = 78). Results Both natural logarithms uAGT/urinary creatinine (ln[uAGT/uCr]) uRenin (ln[uRenin/uCr]) levels were significantly higher compared those (ln[uAGT/uCr]: 4.16 ± 1.13 vs. 3.52 ± 1.21 NDN, P = 0.007; ln[uRenin/uCr]: 5.66 ± 1.60 4.29 ± 1.48 P < 0.001), when estimated glomerular filtration rate (eGFR) uPCR showed no significant difference the two groups. In a subgroup analysis, according amount proteinuria, both uAGT subnephrotic-range (uPCR < 3.5 mg/mg However, nephrotic-range (uPCR ≥ 3.5 mg/mg Cr), only NDN. multiple regression diabetes independent association uRenin. Conclusion Consistently elevated DN, regardless indicates that may proteinuria.
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