The Renin-Angiotensin System and Diabetic Nephropathy

摘要: The renin-angiotensin system (RAS) has key regulatory functions for blood pressure and fluid homeostasis. In addition, dysregulation of the can have maladaptive effects to promote tissue injury in chronic diseases such as hypertension, heart failure, kidney disease. These actions RAS disease pathogenesis are especially apparent diabetic nephropathy, most common cause end-stage renal United States. Evidence a role nephropathy comes from studies animal models randomized clinical trials showing efficacy angiotensin-converting enzyme inhibitors angiotensin-receptor blockers slow progression Widespread applications these therapies range may contributed recent reduction incidence rates We provide general review its nephropathy.