Bone mass after treatment for acute lymphoblastic leukemia in childhood.
作者： K Nysom , K Holm , K F Michaelsen , H Hertz , J Müller
DOI: 10.1200/JCO.1998.16.12.3752
关键词: Endocrinology 、 Case-control study 、 Young adult 、 Internal medicine 、 Acute lymphocytic leukemia 、 Bone mineral 、 Complication 、 Childhood Acute Lymphoblastic Leukemia 、 Osteoporosis 、 Bone disease 、 Gastroenterology 、 Medicine
摘要: PURPOSETo study bone mass after childhood acute lymphoblastic leukemia (ALL) and determine if reduced is related to previous therapy or endocrine status at follow-up.PATIENTS AND METHODSWe studied 95 survivors of ALL who were in first remission a median 11 years (range, 3 23 years) diagnosis had never been irradiated outside cranial field. The was measured by dual-energy x-ray absorptiometry. results compared with data on 396 local controls.RESULTSAdjusted for sex age, the mean whole-body mineral content (BMC) areal density (BMDA) both significantly (0.4 SDs less than predicted value). This mainly caused 33 participants aged 19 older follow-up. In these young adults, height area height, BMC all reduced. indicated that b...
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