Expansion of selection criteria for patients with hepatocellular carcinoma in living donor liver transplantation.
作者： Takashi Ito , Yasutsugu Takada , Mikiko Ueda , Hironori Haga , Yoji Maetani
DOI: 10.1002/LT.21281
关键词: Gastroenterology 、 Liver transplantation 、 Medicine 、 Hepatocellular carcinoma 、 Internal medicine 、 Milan criteria 、 Surgery 、 Living donor liver transplantation 、 Multivariate analysis 、 Carcinoma 、 Severity of illness 、 Proportional hazards model
摘要: In the present study, results of living donor liver transplantation (LDLT) for 125 hepatocellular carcinoma (HCC) patients were analyzed to determine optimal criteria exceeding Milan (MC) but still with predictably good outcomes. On basis pretransplant imaging studies, 70 met MC, and 55 did not. Patients who exceeded MC presented ≤10 tumors all ≤5 cm in diameter (n = 30) displayed 5-year recurrence rates (7.3%) similar those within (9.7%, P 0.8787). According multivariate analysis risk factors among preoperative tumor variables, we have defined new criteria, namely protein induced by vitamin K absence or antagonist-II (PIVKA-II) ≤400 mAU/mL. The 78 showed significantly lower (4.9%) than 40 them (60.5%, < 0.0001). Similarly, survival differed between these groups (86.7% versus 34.4%, respectively; conclusion, selection HCC undergoing LDLT may be safely extended PIVKA-II mAU/mL acceptable Liver Transpl 13: 1637–1644, 2007. © 2007 AASLD.
sci-hub.se 参考文章(29)
Yukihiro Koike, Yasushi Shiratori, Shinpei Sato, Shuntaro Obi, Takuma Teratani, Masatoshi Imamura, Haruhiko Yoshida, Shuichiro Shiina, Masao Omata, Des-γ-carboxy prothrombin as a useful predisposing factor for the development of portal venous invasion in patients with hepatocellular carcinoma Cancer. ,vol. 91, pp. 561- 569 ,(2001) , 10.1002/1097-0142(20010201)91:3<561::AID-CNCR1035>3.0.CO;2-N
Sven Jonas, Wolf O Bechstein, Thomas Steinmüller, Martin Herrmann, Cornelia Radke, Thomas Berg, Utz Settmacher, Peter Neuhaus, Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis Hepatology. ,vol. 33, pp. 1080- 1086 ,(2001) , 10.1053/JHEP.2001.23561
Gerd Otto, Sascha Herber, Michael Heise, Ansgar W. Lohse, Christian Mönch, Fernando Bittinger, Maria Hoppe-Lotichius, Marcus Schuchmann, Anja Victor, Michael Pitton, Response to transarterial chemoembolization as a biological selection criterion for liver transplantation in hepatocellular carcinoma Liver Transplantation. ,vol. 12, pp. 1260- 1267 ,(2006) , 10.1002/LT.20837
Umberto Cillo, Alessandro Vitale, Marco Bassanello, Patrizia Boccagni, Alberto Brolese, Giacomo Zanus, Patrizia Burra, Stefano Fagiuoli, Fabio Farinati, Massimo Rugge, Davide Francesco D'Amico, None, Liver transplantation for the treatment of moderately or well-differentiated hepatocellular carcinoma. Annals of Surgery. ,vol. 239, pp. 150- 159 ,(2004) , 10.1097/01.SLA.0000109146.72827.76
Sun-Lung Tsai, Guan-Tarn Huang, Pei-Ming Yang, Jin-Chuan Sheu, Juei-Low Sung, Ding-Shinn Chen, Plasma des-γ-carboxyprothrombin in the early stage of hepatocellular carcinoma Hepatology. ,vol. 11, pp. 481- 487 ,(1990) , 10.1002/HEP.1840110321
Mureo Kasahara, Yasutsugu Takada, Yasuhiro Fujimoto, Yasuhiro Ogura, Kohei Ogawa, Kenji Uryuhara, Yukihide Yonekawa, Mikiko Ueda, Hiroto Egawa, Koichi Tanaka, Impact of right lobe with middle hepatic vein graft in living-donor liver transplantation. American Journal of Transplantation. ,vol. 5, pp. 1339- 1346 ,(2005) , 10.1111/J.1600-6143.2005.00817.X
Francis Y Yao, Linda Ferrell, Nathan M Bass, Jessica J Watson, Peter Bacchetti, Alan Venook, Nancy L Ascher, John P Roberts, Liver transplantation for hepatocellular carcinoma: Expansion of the tumor size limits does not adversely impact survival Hepatology. ,vol. 33, pp. 1394- 1403 ,(2001) , 10.1053/JHEP.2001.24563
Shimul A. Shah, Jensen C.C. Tan, Ian D. McGilvray, Mark S. Cattral, Sean P. Cleary, Gary A. Levy, Paul D. Greig, David R. Grant, Accuracy of staging as a predictor for recurrence after liver transplantation for hepatocellular carcinoma. Transplantation. ,vol. 81, pp. 1633- 1639 ,(2006) , 10.1097/01.TP.0000226069.66819.7E
Koichi Kozaki, Hiroto Egawa, Mikiko Ueda, Fumitaka Oike, Atsushi Yoshizawa, Atsushi Fukatsu, Yasutsugu Takada, The Role of Apheresis Therapy for ABO Incompatible Living Donor Liver Transplantation: The Kyoto University Experience Therapeutic Apheresis and Dialysis. ,vol. 10, pp. 441- 448 ,(2006) , 10.1111/J.1744-9987.2006.00409.X
Georgios C. Sotiropoulos, Massimo Malag??, Ernesto Molmenti, Andreas Paul, Silvio Nadalin, Eirini Brokalaki, Hilmar K??hl, Olaf Dirsch, Hauke Lang, Christoph E. Broelsch, Liver transplantation for hepatocellular carcinoma in cirrhosis: is clinical tumor classification before transplantation realistic? Transplantation. ,vol. 79, pp. 483- 487 ,(2005) , 10.1097/01.TP.0000152801.82734.74