Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid droplets
作者： Shadi Salloum , Hongliang Wang , Charles Ferguson , Robert G. Parton , Andrew W. Tai
DOI: 10.1371/JOURNAL.PPAT.1003513
关键词: Viral replication 、 RNA-dependent RNA polymerase 、 Virion assembly 、 Lipid droplet 、 Virology 、 Endoplasmic reticulum 、 Cell biology 、 Biology 、 Membrane lipids 、 NS5A 、 RNA virus
摘要: Hepatitis C virus (HCV) is a single-stranded RNA virus that replicates on endoplasmic reticulum-derived membranes. HCV particle assembly is dependent on the association of core protein with cellular lipid droplets (LDs). However, it remains uncertain whether HCV assembly occurs at the LD membrane itself or at closely associated ER membranes. Furthermore, it is not known how the HCV replication complex and progeny genomes physically associate with the presumed sites of virion assembly at or near LDs. Using an …
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