Macrophage-Mediated Destruction of Human Malignant Cells In Vivo

摘要: Macrophages require a plasma component, designated "recognition factor" (RF), for the expression of optimal function. The RF activity was profoundly depleted in from patients with malignant disease, and degree depletion severity state seemed to be related. Since experiments demonstrated that an active significantly inhibited tumor growth, clinical studies were initiated investigate influence intratumor administration fraction. Glucan, potent macrophage activator, also employed alone or combined RF. These undertaken enhance recognition cells by macrophages mobilize activate intralesionally. initial 9 studied had melanoma, adenosquamous carcinoma lung, breast. Control experimental lesions injected; subsequently biopsies performed at varying intervals histologic evaluation. Always when glucan fraction administered intralesionally, size lesion strikingly reduced as short period 5 days. This reduction associated necrosis monocytic infiltrate. In small lesions, resolution complete, whereas large partial. amount injected quantity residual appeared induced nodule increase levels circulating activity.