Experimental and theoretical analysis of poly (β-hydroxybutyrate) formation and consumption in Ralstonia eutropha

摘要: Abstract In this paper a mathematical model is presented to describe poly(β-hydroxybutyrate) (PHB) formation and consumption in Ralstonia eutropha. The based on the hybrid cybernetic modeling approach, which was introduced by Kim et al. [1] allows systematic derivation of equations from elementary mode analysis. An extension approach allow for non quasi-stationary metabolites, i.e. PHB. shown be good agreement with experimental data PHB consumption. used afterwards discuss occurrence multiple steady states continuous bio reactor. It that multiplicity region predicted rather small it argued are therefore unlikely occur practice specific system. Due various desirable features such as accounting cellular regulation at network level dynamics intracellular metabolites moderate complexity, believed constructed most suitable control, optimization monitoring industrial production processes.