Cobalamin and its binding protein in rat milk
作者： L. Raaberg , E. Nexøs , S. S. Poulsen , L. Tollund
DOI: 10.3109/00365518909089132
关键词: Binding protein 、 B vitamins 、 Molar concentration 、 Chemistry 、 Cobalamin 、 Vitamin B12 、 Biochemistry 、 Lactation 、 Stokes radius 、 Haptocorrin 、 Clinical biochemistry 、 General Medicine
摘要: Cobalamin and its binding protein, haptocorrin, are present in rat milk throughout the lactation period. The concentration of cobalamin is approximately 0.3-times unsaturated protein. cobalamin-binding protein varies between 18 nmol l-1 61 1-1. has a Stokes radius 2.49 nm when saturated with 2.61 unsaturated. It binds over broad range pH able to bind cobinamide also. With immunohistochemistry, we find haptocorrin immunoreactivity mammary glands sebaceous nipple.
sci-hub.se 参考文章(12)
CHESTER GOTTLIEB, KAM-SENG LAU, LOUIS R. WASSERMAN, VICTOR HERBERT, Rapid charcoal assay for intrinsic factor (IF), gastric juice unsaturated B12 binding capacity, antibody to IF, and serum unsaturated B12 binding capacity. Blood. ,vol. 25, pp. 875- 884 ,(1965) , 10.1182/BLOOD.V25.6.875.875
H Nagasawa, A device for milk collection from mice. Laboratory Animal Science. ,vol. 29, pp. 633- ,(1979)
E. Nexø, M. Hansen, Skov Olsen, E. Magid, Salivary secretion of rat haptocorrin and amylase is stimulated by vasoactive intestinal polypeptide. Digestion. ,vol. 36, pp. 18- 23 ,(1987) , 10.1159/000199394
Ben E. Sheffy, Nutrition and Nutritional Disorders Veterinary Clinics of North America. ,vol. 8, pp. 7- 29 ,(1978) , 10.1016/S0091-0279(78)50003-8
D. L. Williams, G. H. Spray, Some observations on the vitamin B12 content of rat's milk. British Journal of Nutrition. ,vol. 25, pp. 295- 298 ,(1971) , 10.1079/BJN19710090
H Kudo, G Ohshio, K Ogawa, Y Wakatsuki, M Inada, Y Hamashima, T Miyake, Distribution of vitamin B12 R binder in normal human tissues: an immunohistochemical study. Journal of Histochemistry and Cytochemistry. ,vol. 35, pp. 855- 859 ,(1987) , 10.1177/35.8.3298426
Ebba Nexø, Mads Hansen, Steen Seier Poulsen, Peter Skov Olsen, Characterization and immunohistochemical localization of rat salivary cobalamin-binding protein and comparison with human salivary haptocorrin Biochimica et Biophysica Acta. ,vol. 838, pp. 264- 269 ,(1985) , 10.1016/0304-4165(85)90088-1
Ebba Nexø, Peter Gimsing, Insolubilized pure human intrinsic factor used for quantitation of cobalamins in serum Scandinavian Journal of Clinical & Laboratory Investigation. ,vol. 41, pp. 465- 468 ,(1981) , 10.3109/00365518109090484
Ben L. Hom, Stokes radius of 57Co-labeled vitamin B12-transcobalamin I and II determined by Sephadex gel filtration. Biochimica et Biophysica Acta. ,vol. 175, pp. 20- 23 ,(1969) , 10.1016/0005-2795(69)90140-8
D P Sandberg, J A Begley, C A Hall, The content, binding, and forms of vitamin B12 in milk. The American Journal of Clinical Nutrition. ,vol. 34, pp. 1717- 1724 ,(1981) , 10.1093/AJCN/34.9.1717