C5b-9 membrane attack complex mediates endothelial cell apoptosis in experimental glomerulonephritis.

作者: Jeremy Hughes , Masaomi Nangaku , Charles E. Alpers , Stuart J. Shankland , William G. Couser

DOI: 10.1152/AJPRENAL.2000.278.5.F747

关键词: BiologyGlomerulonephritisImmunologyEndothelial stem cellProgrammed cell deathInflammationCell biologyComplement membrane attack complexPathogenesisRenal glomerulusApoptosis

摘要: … integrity and renal function. This study demonstrates the specific role of C5b-9 in the induction … Indeed, apoptosis has been demonstrated to be involved in the deletion of resident renal …

参考文章(69)
J Savill, A Mooney, R J Johnson, K Gordon, C Hugo, J Hughes, Neutrophil fate in experimental glomerular capillary injury in the rat. Emigration exceeds in situ clearance by apoptosis. American Journal of Pathology. ,vol. 150, pp. 223- 234 ,(1997)
Jason S. Koh, Jerrold S. Levine, Wilfred Lieberthal, Necrosis and apoptosis in acute renal failure. Seminars in Nephrology. ,vol. 18, pp. 505- 518 ,(1998)
Couser Wg, New insights into mechanisms of immune glomerular injury. Western Journal of Medicine. ,vol. 160, pp. 440- 446 ,(1994)
G C Gobe, R A Axelsen, Genesis of renal tubular atrophy in experimental hydronephrosis in the rat. Role of apoptosis. Laboratory Investigation. ,vol. 56, pp. 273- 281 ,(1987)
Aly Karsan, Guy G. Poirier, John M. Harlan, Esther Yee, Ruth Craig, Ping Zhou, Fibroblast growth factor-2 inhibits endothelial cell apoptosis by Bcl-2-dependent and independent mechanisms. American Journal of Pathology. ,vol. 151, pp. 1775- 1784 ,(1997)
A K Campbell, R A Daw, M B Hallett, J P Luzio, Direct measurement of the increase in intracellular free calcium ion concentration in response to the action of complement Biochemical Journal. ,vol. 194, pp. 551- 560 ,(1981) , 10.1042/BJ1940551
F Klatter, Pjcv Vriesman, E Vanbussel, H Vangoor, Am Duijvestijn, Gd Majoor, Antibodies defining rat endothelial cells: RECA-1, a pan-endothelial cell-specific monoclonal antibody. Laboratory Investigation. ,vol. 66, pp. 459- 466 ,(1992)
C. D. Dijkstra, E. A. Döpp, P. Joling, G. Kraal, The Heterogeneity of Mononuclear Phagocytes in Lymphoid Organs: Distinct Macrophage Subpopulations in Rat Recognized by Monoclonal Antibodies ED1, ED2 and ED3 Microenvironments in the Lymphoid System. ,vol. 54, pp. 409- 419 ,(1985) , 10.1007/978-1-4613-2463-8_50
Y Sugisaki, Y Masuda, M Ishizaki, N Yamanaka, H Kitamura, A Shimizu, Rare glomerular capillary regeneration and subsequent capillary regression with endothelial cell apoptosis in progressive glomerulonephritis. American Journal of Pathology. ,vol. 151, pp. 1231- 1239 ,(1997)
T J Lang, D F Carney, M L Shin, Multiple signal messengers generated by terminal complement complexes and their role in terminal complement complex elimination. Journal of Immunology. ,vol. 145, pp. 623- 629 ,(1990)