Is Bacillus an Alternative Expression System

摘要: In this review we consider the possible use of Bacillus subtilis as a host for production heterologous proteins. There are several potential advantages to be gained from organism, particularly its efficient secretion proteins into growth medium. Although it is unlikely become first choice certain types protein, example potentially therapeutic mammalian proteins, which often undergo specific and necessary post-translation modifications, there certainly some important groups industrial enzymes, Bacilli already heavily used. The market such enzymes likely grow very rapidly recombinant DNA methods allow diverse little characterised microorganisms. Exploitation these natural products will depend upon development versatile robust expression systems, growing evidence that useful system. On other hand, has undesirable properties host, elaboration proteases, can cause loss product by degradation. If problems overcome, in assess technical difficulties involved, then B. may turn out many new enzymes.