Activity-dependent neuroprotective protein (ADNP)/NAP (CP201): Autism, schizophrenia, and Alzheimer’s disease
作者： Illana Gozes
DOI: 10.1016/B978-0-12-814037-6.00001-X
关键词: Davunetide 、 Biology 、 Schizophrenia 、 Neuroscience 、 Neuroprotection 、 Drug candidate 、 Disease 、 Nap 、 Autism
摘要: Abstract ADNP is a large protein, presenting key signature motifs for macromolecular interactions linked with cognition, emphasis on social impaired, example, in autism, schizophrenia, and Alzheimer’s disease (AD). The connection to AD was recently reviewed. Here, I will mention attributed followed by description of the syndrome (within autism spectrum disorders—ASD), schizophrenia ADNP, finally updates AD. Importantly, when we cloned discovered an active eight-amino acid neuroprotective snippet that have named NAP (NAPVSIPQ), drug candidate name davunetide or CP201. Thus, be entwined CP201 (NAP) protection against deficiencies beyond.
elsevier.com
sci-hub.se 参考文章(108)
Illana Gozes, Adva Yeheskel, Metsada Pasmanik-Chor, Activity-Dependent Neuroprotective Protein (ADNP): A Case Study for Highly Conserved Chordata-Specific Genes Shaping the Brain and Mutated in Cancer Journal of Alzheimer's Disease. ,vol. 45, pp. 57- 73 ,(2015) , 10.3233/JAD-142490
Illana Gozes, Celine Helsmoortel, Geert Vandeweyer, Nathalie Van der Aa, Frank Kooy, Sandra Bedrosian Sermone, The Compassionate Side of Neuroscience: Tony Sermone's Undiagnosed Genetic Journey--ADNP Mutation. Journal of Molecular Neuroscience. ,vol. 56, pp. 751- 757 ,(2015) , 10.1007/S12031-015-0586-6
Illana Gozes, Tal Iram, Evgenia Maryanovsky, Carmit Arviv, Liora Rozenberg, Yulie Schirer, Eliezer Giladi, Sharon Furman-Assaf, Novel tubulin and tau neuroprotective fragments sharing structural similarities with the drug candidate NAP (Davuentide). Journal of Alzheimer's Disease. ,vol. 40, ,(2014) , 10.3233/JAD-131664
Geert Vandeweyer, Céline Helsmoortel, Anke Van Dijck, Anneke T. Vulto-van Silfhout, Bradley P. Coe, Raphael Bernier, Jennifer Gerdts, Liesbeth Rooms, Jenneke van den Ende, Madhura Bakshi, Meredith Wilson, Ann Nordgren, Laura G. Hendon, Omar A. Abdulrahman, Corrado Romano, Bert B.A. de Vries, Tjitske Kleefstra, Evan E. Eichler, Nathalie Van der Aa, R. Frank Kooy, The Transcriptional Regulator ADNP Links the BAF (SWI/SNF) Complexes With Autism American Journal of Medical Genetics Part C-seminars in Medical Genetics. ,vol. 166, pp. 315- 326 ,(2014) , 10.1002/AJMG.C.31413
Markus M. Heimesaat, André Fischer, Anja A. Kühl, Ulf B. Göbel, Illana Gozes, Stefan Bereswill, Anti-Inflammatory Properties of NAP in Acute Toxoplasma Gondii-Induced Ileitis in Mice. European journal of microbiology and immunology. ,vol. 5, pp. 210- 220 ,(2015) , 10.1556/1886.2015.00025
Anna Malishkevich, Janina Leyk, Olaf Goldbaum, Christiane Richter-Landsberg, Illana Gozes, ADNP/ADNP2 expression in oligodendrocytes: implication for myelin-related neurodevelopment. Journal of Molecular Neuroscience. ,vol. 57, pp. 304- 313 ,(2015) , 10.1007/S12031-015-0640-4
Bradley P Coe, Kali Witherspoon, Jill A Rosenfeld, Bregje W M van Bon, Anneke T Vulto-van Silfhout, Paolo Bosco, Kathryn L Friend, Carl Baker, Serafino Buono, Lisenka E L M Vissers, Janneke H Schuurs-Hoeijmakers, Alex Hoischen, Rolph Pfundt, Nik Krumm, Gemma L Carvill, Deana Li, David Amaral, Natasha Brown, Paul J Lockhart, Ingrid E Scheffer, Antonino Alberti, Marie Shaw, Rosa Pettinato, Raymond Tervo, Nicole de Leeuw, Margot R F Reijnders, Beth S Torchia, Hilde Peeters, Elizabeth Thompson, Brian J O'Roak, Marco Fichera, Jayne Y Hehir-Kwa, Jay Shendure, Heather C Mefford, Eric Haan, Jozef Gécz, Bert B A de Vries, Corrado Romano, Evan E Eichler, Refining analyses of copy number variation identifies specific genes associated with developmental delay Nature Genetics. ,vol. 46, pp. 1063- 1071 ,(2014) , 10.1038/NG.3092
Tomoya Nakamachi, Hirokazu Ohtaki, Sachiko Yofu, Kenji Dohi, Jun Watanabe, Daisuke Hayashi, Ryosuke Matsuno, Naoko Nonaka, Kazuo Itabashi, Seiji Shioda, Pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1R) co-localizes with activity-dependent neuroprotective protein (ADNP) in the mouse brains Regulatory Peptides. ,vol. 145, pp. 88- 95 ,(2008) , 10.1016/J.REGPEP.2007.09.025
P. Sokolowska, S. Passemard, A. Mok, L. Schwendimann, I. Gozes, P. Gressens, Neuroprotective effects of NAP against excitotoxic brain damage in the newborn mice: implications for cerebral palsy. Neuroscience. ,vol. 173, pp. 156- 168 ,(2011) , 10.1016/J.NEUROSCIENCE.2010.10.074
Kerstin Mosch, Henriette Franz, Szabolcs Soeroes, Prim B. Singh, Wolfgang Fischle, HP1 Recruits Activity-Dependent Neuroprotective Protein to H3K9me3 Marked Pericentromeric Heterochromatin for Silencing of Major Satellite Repeats PLoS ONE. ,vol. 6, pp. e15894- ,(2011) , 10.1371/JOURNAL.PONE.0015894