Role of calcitriol in prevention of osteoporosis: Part I
作者： Marc K. Drezner , Teresa Nesbitt
DOI: 10.1016/0026-0495(90)90266-F
关键词: Calcitriol 、 Bone density 、 Postmenopausal osteoporosis 、 Osteoporosis 、 In patient 、 Bone resorption 、 Endocrinology 、 Perforation (oil well) 、 Bone mass 、 Internal medicine 、 Medicine
摘要: Prevention of postmenopausal osteoporosis is an alternative to the currently problematic goal reversing trabecular plate thinning and perforation that constitute major pathologic defects in patients with established osteoporosis. 1,25(OH)2D3 (calcitriol) has been suggested as a drug may decrease bone resorption sufficiently preserve structure perimenopausal women. In present study, we compared effects calcitriol investigational analog, 1,25,26-(OH )3Δ22-D3 (Ro-23-8525), those inert vehicle maintaining mass oophorectomized adult beagles. these studies, used dual-energy radiography serially quantitate density control treated animals. Treatment for 1 year either agent resulted no evidence hypercalcemia or decreased renal function. Moreover, Ro-23-8525 effectively abolished loss observed untreated controls. Indeed, animals displayed variations similar sham-operated These data suggest be potentially effective agents prophylaxis
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sci-hub.se 参考文章(23)
Pierre J. Meunier, Cellular mechanisms of bone remodeling evaluated at the intermediary level of organization of bone. Advances in Experimental Medicine and Biology. ,vol. 208, pp. 247- 254 ,(1986) , 10.1007/978-1-4684-5206-8_31
James W. Pugh, Robert M. Rose, Eric L. Radin, Elastic and viscoelastic properties of trabecular bone: dependence on structure Journal of Biomechanics. ,vol. 6, pp. 475- 485 ,(1973) , 10.1016/0021-9290(73)90006-7
S.A. Duursma, J.H. Glerum, A. Van Dijk, R. Bosch, H. Kerkhoff, J. Van Putten, J.A. Raymakers, Responders and non-responders after fluoride therapy in osteoporosis. Bone. ,vol. 8, pp. 131- 136 ,(1987) , 10.1016/8756-3282(87)90011-1
Mark Schwartz, Ian Anwah, Roger N. Levy, Variations in treatment of postmenopausal osteoporosis. Clinical Orthopaedics and Related Research. pp. 180- 184 ,(1985) , 10.1097/00003086-198501000-00025
Gillian R. Snow, C. Anderson, Short-term chronic fluoride administration and trabecular bone remodeling in beagles: a pilot study. Calcified Tissue International. ,vol. 38, pp. 217- 221 ,(1986) , 10.1007/BF02556713
W.B. High, Effects of orally administered prostaglandin E-2 on cortical bone turnover in adult dogs: a histomorphometric study. Bone. ,vol. 8, pp. 363- 373 ,(1987) , 10.1016/8756-3282(87)90068-8
John F. Aloia, Ashok Vaswani, James K. Yeh, Kenneth Ellis, Seiichi Yasumura, Stanton H. Cohn, Calcitriol in the treatment of postmenopausal osteoporosis The American Journal of Medicine. ,vol. 84, pp. 401- 408 ,(1988) , 10.1016/0002-9343(88)90259-8
Susan M. Ott, Calcitriol Treatment Is Not Effective in Postmenopausal Osteoporosis Annals of Internal Medicine. ,vol. 110, pp. 267- 274 ,(1989) , 10.7326/0003-4819-110-4-267
G. A. Dannucci, R. B. Martin, P. Patterson-Buckendahl, Ovariectomy and trabecular bone remodeling in the dog. Calcified Tissue International. ,vol. 40, pp. 194- 199 ,(1987) , 10.1007/BF02556621
A. Caniggia, R. Nuti, M. Galli, F. Loré, V. Turchetti, G. A. Righi, Effect of a long-term treatment with 1,25-dihydroxyvitamin D3 on osteocalcin in postmenopausal osteoporosis Calcified Tissue International. ,vol. 38, pp. 328- 332 ,(1986) , 10.1007/BF02555745