A Map of the Interactome Network of the Metazoan C. elegans

作者: Siming Li , Christopher M Armstrong , Nicolas Bertin , Hui Ge , Stuart Milstein

DOI: 10.1126/SCIENCE.1091403

关键词: BiologyGeneticsProteomeCaenorhabditis elegansIn silicoComputational biologyPhenomeGenomicsInteractomeProteomicsProtein–protein interaction prediction

摘要: To initiate studies on how protein-protein interaction (or “interactome”) networks relate to multicellular functions, we have mapped a large fraction of the Caenorhabditis elegans …

参考文章(26)
Hui Ge, Albertha J.M Walhout, Marc Vidal, Integrating 'omic' information: a bridge between genomics and systems biology. Trends in Genetics. ,vol. 19, pp. 551- 560 ,(2003) , 10.1016/J.TIG.2003.08.009
Kartik S Pappu, Rui Chen, Brooke W Middlebrooks, Catherine Woo, Ulrike Heberlein, Graeme Mardon, Mechanism of hedgehog signaling during Drosophila eye development. Development. ,vol. 130, pp. 3053- 3062 ,(2003) , 10.1242/DEV.00534
P Taylor, K Bennett, K Boutilier, L Yang, C Wolting, I Donaldson, S Schandorff, J Shewnarane, M Vo, J Taggart, M Goudreault, B Muskat, C Alfarano, D Dewar, Z Lin, K Michalickova, AR Willems, H Sassi, PA Nielsen, KJ Rasmussen, JR Andersen, LE Johansen, LH Hansen, H Jespersen, A Podtelejnikov, E Nielsen, J Crawford, V Poulsen, BD Sorensen, J Matthiesen, RC Hendrickson, F Gleeson, T Pawson, MF Moran, D Durocher, M Mann, CW Hogue, D Figeys, M Tyers, Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry Nature. ,vol. 415, pp. 180- 183 ,(2002) , 10.1038/415180A
D. S. Goldberg, F. P. Roth, Assessing experimentally derived interactions in a small world Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 4372- 4376 ,(2003) , 10.1073/PNAS.0735871100
M. Pellegrini, E. M. Marcotte, M. J. Thompson, D. Eisenberg, T. O. Yeates, Assigning protein functions by comparative genome analysis protein phylogenetic profiles Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 4285- 4288 ,(2000) , 10.1073/PNAS.96.8.4285
F Jacob, Evolution and tinkering Science. ,vol. 196, pp. 1161- 1166 ,(1977) , 10.1126/SCIENCE.860134
M. Hanazawa, M. Mochii, N. Ueno, Y. Kohara, Y. Iino, Use of cDNA subtraction and RNA interference screens in combination reveals genes required for germ-line development in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 8686- 8691 ,(2001) , 10.1073/PNAS.141004698
Peter Uetz, Loic Giot, Gerard Cagney, Traci A Mansfield, Richard S Judson, James R Knight, Daniel Lockshon, Vaibhav Narayan, Maithreyan Srinivasan, Pascale Pochart, Alia Qureshi-Emili, Ying Li, Brian Godwin, Diana Conover, Theodore Kalbfleisch, Govindan Vijayadamodar, Meijia Yang, Mark Johnston, Stanley Fields, Jonathan M Rothberg, None, A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae Nature. ,vol. 403, pp. 623- 627 ,(2000) , 10.1038/35001009