Modulation of Caenorhabditis elegans immune response and modification of Shigella endotoxin upon interaction
作者： Periyanaina Kesika , Mani Iyer Prasanth , Krishnaswamy Balamurugan , None
关键词: Immune system 、 Microbiology 、 Pathogen-associated molecular pattern 、 Pharyngeal pumping 、 Biology 、 Model organism 、 Caenorhabditis elegans 、 Lipopolysaccharide 、 Innate immune system 、 Shigella
摘要: To analyze the pathogenesis at both physiological and molecular level using model organism, Caenorhabditis elegans different developmental stages in response to Shigella spp. its pathogen associated patterns such as lipopolysaccharide. The solid plate liquid culture-based infection assays revealed that infects C. had an impact on brood size pharyngeal pumping rate. LPS of was toxic elegans. qPCR analysis host innate immune genes have been modulated upon infections challenges. Non-destructive performed kinetically assess alterations during interaction with modulation attributed surrendering system by favoring infection. appeared a major role Shigella-mediated employs tactic behavior modifying content escape from recognition system.
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