Regulation of antigen-expressing dendritic cells by double negative regulatory T cells
作者： Julia Fang Gao , Megan S. Ford McIntyre , Stephen C. Juvet , Jun Diao , Xujian Li
关键词: Transgene 、 Cell biology 、 Biology 、 Immune system 、 CD86 、 Antigen 、 Downregulation and upregulation 、 Immunology 、 CD3 、 Double negative 、 CD80
摘要: TCRαβ+CD3+CD4−CD8−NK1.1− double negative (DN) Tregs comprise 1–3% of peripheral T lymphocytes in mice and humans. It has been demonstrated that DN can suppress allo-, xeno- auto-immune responses an Ag-specific fashion. However, the mechanisms by which regulate immune remain elusive. Whether DCs not investigated previously. In this study, we demonstrate express a high level CTLA4 are able to down-regulate costimulatory molecules CD80 CD86 expressed on Ag-expressing mature (mDCs). from KO were downregulate expression, indicating is critical for Treg-mediated downregulation molecule expression DCs. Furthermore, could kill both immature allogeneic DCs, as well Ag-loaded syngeneic manner vitro vivo, mainly through Fas-FasL pathway. These data demonstrate, first time, potent regulators may have potential be developed novel suppression treatment.
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