Donor double-negative Treg promote allogeneic mixed chimerism and tolerance.

摘要: Bone marrow (BM) transplantation is an efficient approach to develop donor-specific tolerance and prevent chronic rejection. Allogeneic BM limited by donor T cell-mediated graft-versus-host disease, requirement of cytoreduction high numbers cells. In addition these drawbacks, recent studies demonstrate that not only cells, but also NK cells can mediate rejection, long-term mixed chimerism depends on cell tolerance. Thus, another potential barrier against engraftment important target in efforts induce transplant We have previously identified a novel type Treg with the phenotype TCRαβ+CD3+CD4–CD8– (double-negative, DN). others demonstrated DN-Treg effectively suppress anti-donor responses. this study, we found donor-derived allogeneic graft rejection both parent-to-F1 fully MHC-mismatched models. Perforin FasL play roles suppression Furthermore, adoptive transfer promote stable without inducing disease. These results control innate immune responses engraftment.