Chimeric donor cells play an active role in both induction and maintenance phases of transplantation tolerance induced by mixed chimerism.
作者： Akira Kanamoto , Takashi Maki
DOI: 10.4049/JIMMUNOL.172.3.1444
关键词:
摘要: Donor hemopoietic cell engraftment is considered to be an indicator of allograft tolerance. We depleted chimerism with cells specifically presensitized the bone marrow donor investigate its role in mixed chimera-induced Three experimental models were used: model A, B10.A B6 ( a anti-b cells) injected into (B6 × D2)F 1 → chimeras grafted DBA/2 skin; B, anti-B6 prepared chimeras, thus unresponsive anti-b/tol-d cells), and C, (BALB/c B6)F CBA d/b anti-k CBA)F BALB/c skin. Skin was on day 30. Injection each type before skin grafting abolished prevented acceptance. after resulted different outcomes depending models. In injection completely caused rejection. markedly reduced, but did not deplete, peripheral maintained survival. reduced background levels failed cause graft rejection, probably due persistence which share MHC grafts. Together, results show that presence chimeric essential both induction maintenance phases tolerance induced by chimerism.
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