Channel specificity in antiarrhythmic drug action. Mechanism of potassium channel block and its role in suppressing and aggravating cardiac arrhythmias.

摘要: Although work on class III antiarrhythmics remains at an early stage, these agents still appear to possess greater efficacy and less proarrhythmia than conventional I in those experimental arrhythmia models considered be most representative of the clinical situation. prolongation repolarization carries with its own tendency for pause-dependent arrhythmogenesis (i.e., torsade de pointes), available data suggest that this may a function nonspecificity potassium channel block rather general characteristic activity. The availability new more selective blockers specific cardiac channels under development as have already helped clarify basic questions about ionic mechanism heart, one hopes growing base will eventually determine relative safety preventing symptomatic life-threatening arrhythmias.