Prevention of ventricular fibrillation by dextrorotatory sotalol in a conscious canine model of sudden coronary death

摘要: The antiarrhythmic and antifibrillatory actions of the dextrorotatory isomer sotalol, administered in a multiple-dose regimen, were evaluated conscious dogs 3 to 5 days after anterior myocardial infarction. intravenous administration d-sotalol, four 8 mg/kg doses over 24-hour treatment period, suppressed induction ventricular tachycardia by programmed electrical stimulation six nine tested, slowed rate induced tachyarrhythmia two remaining three dogs, provided significant protection (5 d-sotalol vs 0 vehicle control) against development fibrillation response ischemia at site distant previous Increases refractoriness QTc paced QT intervals suggest that class III electrophysiologic contribute properties sotalol this animal model. degree beta-adrenergic receptor blockade produced dose regimen was negligible. These findings potential utility prevention setting infarction, particularly when is undesirable or contraindicated.