Floctafenine: a Valid Alternative in Patients with Adverse Reactions to Nonsteroidal Anti-inflammatory Drugs

摘要: Background Choosing an alternative antiinflammatory agent for a patient who has suffered adverse reactions to nonsteroidal drugs is common problem in clinical practice, and it complicated by the possibility of nonimmunologic cross reactivity among various members this drug class. Objective We performed retrospective study based on oral challenge results 150 patients with histories one or more drugs. The tested included floctafenine, analgesic fenamic acid group, nimesulide, paracetamol (acetaminophen). Patients methods One hundred fifty received challenges floctafenine; 101 were also challenged nimesulide paracetamol. administered under single-blinded conditions. One-fourth therapeutic dose (floctafenine, 200 mg; 100 paracetamol, 500 mg) was initially; remaining 3/4 given hour later if no symptoms had developed initial administration. In rhinitis and/or bronchial asthma unrelated use those whose bronchospastic rhinitic symptoms, FEV 1 measured. response considered positive any following developed: erythema, pruritus accompanied urticaria/angioedema, rhinorrhea, nasal obstruction, sneezing, dyspnea cough associated decrease at least 20% , hypotension. Results Floctafenine 13/150 (8.7%). Nimesulide provoked 9/101 (8.9%). All occurred within 24 hours challenge. None reacted than tested. Conclusions Our findings confirm other investigators regarding do not tolerate aspirin drugs, although percentage observed present somewhat higher that reported some groups. indicates relatively weak cyclooxygenase inhibitor, can be valid many react adversely