Optical Coherence Tomography Angiography to Distinguish Changes of Choroidal Neovascularization after Anti-VEGF Therapy: Monthly Loading Dose versus Pro Re Nata Regimen

摘要: Purpose. To compare the qualitative and quantitative choroidal neovascularization (CNV) changes after antivascular endothelial growth factor (anti-VEGF) therapy in treatment-naive treated eyes with age-related macular degeneration (AMD) using optical coherence tomography angiography (OCTA). Methods. Consecutive patients neovascular AMD underwent multimodal imaging, including OCTA (AngioPlex, CIRRUS HD-OCT model 5000; Carl Zeiss Meditec, Inc., Dublin, OH) at baseline three monthly follow-up visits. Treatment-naive undergoing anti-VEGF loading phase were included group A, while B. Qualitative analyses performed on outer retina to choriocapillaris (ORCC) slab. CNV size was measured a free image analysis software (ImageJ, open-source imaging processing software, 2.0.0). Results. Twenty-five of 25 enrolled our study (mean age 78.32 ± 6.8 years): 13 A 12 While revealed no significant differences from two groups, showed decrease lesion area ( ); B, change observed during ). Conclusion. secondary respond differently therapy. This should be taken into account when for or planning therapeutic strategies.