Simultaneous in-cell derivatization pressurized liquid extraction for the determination of multiclass preservatives in leave-on cosmetics.

摘要: An effective one-step sample preparation methodology for the determination of multiclass preservatives in cosmetics has been developed, applying, first time to this kind matrix, pressurized liquid extraction (PLE) and a very simple, cheap, fast derivatization procedure: acetylation with acetic anhydride pyridine. A multifactorial experimental design used evaluate optimize main parameters potentially affecting process. In final conditions was mixed Florisil as dispersing sorbent extracted ethyl acetate 15 min at 120 °C. One goals work demonstrate possibility carrying out direct cosmetic preservative by simply adding reagents into PLE cell. The extract then analyzed GC/MS without any further cleanup or concentration step. accuracy, precision, linearity, detection limits (LODs) were evaluated assess performance th...