Effect of rotavirus vaccine on childhood diarrhea mortality in five Latin American countries
作者： Angel Paternina-Caicedo , Umesh D. Parashar , Nelson Alvis-Guzmán , Lucia Helena De Oliveira , Andres Castaño-Zuluaga
DOI: 10.1016/J.VACCINE.2015.06.058
关键词: Demography 、 Medicine 、 Environmental protection 、 Mortality rate 、 Rotavirus vaccine 、 Diarrhea 、 Confidence interval 、 Latin Americans 、 Panama 、 Child mortality 、 Childhood diarrhea
摘要: Abstract Background The aim of this study was to estimate the association between rotavirus vaccine (RV) introduction and reduction all-cause diarrhea death rates among children in five Latin American countries that introduced RV 2006. Methods Diarrhea mortality data gathered from 2002 until 2009 Pan Health Organization Mortality Database for “vaccine adopter” (Brazil, El Salvador, Mexico, Nicaragua, Panama) 2006 four “control” (Argentina, Chile, Costa Rica, Paraguay) did not introduce by 2009. Time trend analyses were carried out, effects 95% confidence intervals (CI) estimated. Results Each adopter countries, except Panama, showed a significant declining during post-vaccine period 2009, whereas no decline seen control these years. Furthermore, trends both Conclusion All decrease diarrhea-related deaths after implementation, even adjusting over time mortality. These strongly support continuous efforts increase vaccination coverage vaccines, particularly with high levels child diarrhea.
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