Steroid-induced ocular hypertension in normal sheep.

摘要: PURPOSE. To determine whether the ovine eye develops elevation of intraocular pressure (IOP) in response to corticosteroid applied topically. METHODS. IOP was monitored by Perkins applanation tonometry a group 18 sheep receiving topically administered 0.5% prednisolone acetate one (experimental), three times daily, for period 3 or four 4 weeks after establishment baseline values. readings were converted actual mm Hg using calibration curve derived from vivo manometric measurements. an additional 1 discontinuation treatment. RESULTS. Baseline normal 10.6 ± 1.4 (mean SD; n = 36 eyes). The experimental eyes began increase week treatment all and reached peak later (27.5 vs. 11.7 fellow, control eye; P < 0.001). After instillation, treated declined values over course weeks. CONCLUSIONS. Ovine exhibit robust steroid-induced ocular hypertensive response, with 100% occurrence this trial. mechanisms glaucoma may be related those involved primary open-angle could provide insight into clues its