The molecular underpinning of lobular histological growth pattern: a genome-wide transcriptomic analysis of invasive lobular carcinomas and grade- and molecular subtype-matched invasive ductal carcinomas of no special type.

摘要: Invasive lobular carcinoma (ILC) is the most frequent special type of breast cancer. The majority these tumours are low histological grade, express hormone receptors, and lack HER2 expression. pleomorphic variant ILCs (PLCs) characterized by atypical cells with nuclei reported to have an aggressive clinical behaviour. Expression profiling studies demonstrated that classic preferentially display a luminal phenotype, whereas PLCs may be luminal, or molecular apocrine subtypes. aims this study were two-fold: determine transcriptomic characteristics carcinomas define genome-wide differences between PLCs. To ILCs, minimizing impact grade subtype on analysis, we subjected series grade- subtype-matched invasive ductal (IDCs) gene expression using oligonucleotide microarrays. Hierarchical clustering analysis formed separate cluster supervised revealed 5.8% transcriptionally regulated genes significantly differentially expressed in compared IDCs. displayed down-regulation E-cadherin related actin cytoskeleton remodelling, protein ubiquitin, DNA repair, cell adhesion, TGF-beta signalling; up-regulation transcription factors/immediate early genes, lipid/prostaglandin biosynthesis migration-associated genes. Supervised less than 0.1% tumour Our results demonstrate differ from IDCs cell-to-cell signalling, signalling. However, remarkably similar at level should considered as part spectrum lesions.