Pharmaceutical compsns. for intravenous or intra-coronary admin. - are aq. emulsions contg. 1,4-di:hydro:pyridine calcium antagonist, natural oil and phosphatidyl-choline or phosphatidyl-ethanolamine

摘要: Pharmaceutical compsns. comprise (a) a 1,4-dihydropyridine calcium antagonist, (b) at least 1 natural oil, (c) 3-sn-phosphatidylcholine and/or phosphatidylethanolamine and (d) water. is pref. nifedipine, nimodipine, nitendipine, isradipine, nicardipine or nisoldipine esp. nifedipine nimodipine. Further, compsn. contains 0.005-0.2 wt.% (a), 5-40 (b), 0.5-6.5 58-94 (d). Soya safflower coconut wheatgerm sunflower olive oil fish can be present as the oil. The phosphatidylcholine soya egg lecithin which may partly fully hydrogenated. Compsns. also contain satd. unsatd. fatty acids, palmitic, palmitoleic, linoleic linolenic acid their alkali salts, well glycerol sorbitol (for isotonisation). USE/ADVANTAGE - Prepns. are used for i.v. intracoronary admin. by injection infusion. aq. emulsions drug in therapeutically high concns. e.g. 10-25 mg/100 ml. avoid potential health risks associated with of conventional prepns. contg. alcohol Macrogols carriers.