Pharmaceutical nanosuspensions for medicament administration as systems with increased saturation solubility and speed of dissolution

摘要: Provided is a drug carrier comprising particles of at least one pure active compound which insoluble, only sparingly soluble or moderately in water, aqueous media and/or organic solvents, wherein said ingredient solid room temperature and has an average diameter, determined by photon correlation spectroscopy (PCS) 10 nm to 1,000 nm, the proportion larger than 5 μm total population being less 0.1% (number distribution with Coulter counter), and, when introduced into increased saturation solubility rate dissolution compared powders prepared using ultrasonic probe, ball mill pearl mill, having been comminuted, without prior conversion melt, cavitation shearing impact forces introduction high amount energy.