Resveratrol nanosuspensions for dermal application--production, characterization, and physical stability.
作者： C. M. Keck , K. Ofori-Kwakye , R. H. Müller , S. Kobierski
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摘要: Nanosuspensions of the anti-oxidant resveratrol (5%) were produced for dermal application. Production was performed by high pressure homogenization, applying 1.500 bar up to 30 cycles. Four nanosuspensions were investigated using the stabilizers Tween 80, Poloxamer 188, Plantacare 2000 and Inutec SP1, 1% and 2% respectively. The nanosuspensions were characterized regarding size (photon correlation spectroscopy, laser diffraction), zeta potential and crystallinity. Nanocrystal sizes were about 150 nm (Poloxamer, Plantacare) …
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researchgate.net 参考文章(24)
Lee Jia, Hong Wong, Cesario Cerna, Steve D. Weitman, Effect of nanonization on absorption of 301029: Ex vivo and in vivo pharmacokinetic correlations determined by liquid chromatography/mass spectrometry Pharmaceutical Research. ,vol. 19, pp. 1091- 1096 ,(2002) , 10.1023/A:1019829622088
Yoel Sasson, Ganit Levy-Ruso, Ofer Toledano, Isaac Ishaaya, Nanosuspensions: Emerging Novel Agrochemical Formulations Insecticides Design Using Advanced Technologies. pp. 1- 39 ,(2007) , 10.1007/978-3-540-46907-0_1
S. Renaud, R. Gueguen, The French Paradox and Wine Drinking Novartis Foundation Symposium 216 - Alcohol and Cardiovascular Diseases. ,vol. 216, pp. 208- 222 ,(2007) , 10.1002/9780470515549.CH13
Robert Becker, Bernd Kruss, Rainer H. Muller, Katrin Peters, Pharmaceutical nanosuspensions for medicament administration as systems with increased saturation solubility and speed of dissolution Official Gazette of the United States Patent and Trademark Office Patents. ,vol. 1218, pp. 1181- ,(1995)
John F. Bishop, David A. Czekai, Kenneth C. Cundy, Gary G. Liversidge, Surface modified drug nanoparticles ,(1992)
Isaak Effendy, Howard I. Maibach, Surfactants and experimental irritant contact dermatitis Contact Dermatitis. ,vol. 33, pp. 217- 225 ,(1995) , 10.1111/J.1600-0536.1995.TB00470.X
J. Sun, S.L. Simon, The melting behavior of aluminum nanoparticles Thermochimica Acta. ,vol. 463, pp. 32- 40 ,(2007) , 10.1016/J.TCA.2007.07.007
Hongyu Piao, Noriho Kamiya, Akihiko Hirata, Takeru Fujii, Masahiro Goto, A novel solid-in-oil nanosuspension for transdermal delivery of diclofenac sodium. Pharmaceutical Research. ,vol. 25, pp. 896- 901 ,(2008) , 10.1007/S11095-007-9445-7
C KECK, R MULLER, Drug nanocrystals of poorly soluble drugs produced by high pressure homogenisation European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 62, pp. 3- 16 ,(2006) , 10.1016/J.EJPB.2005.05.009
Mitra Mosharraf, Christer Nyström, Apparent solubility of drugs in partially crystalline systems. Drug Development and Industrial Pharmacy. ,vol. 29, pp. 603- 622 ,(2003) , 10.1081/DDC-120021310