Effect of zinc supplementation on E-ADA activity, seric zinc, and cytokines levels of Trypanosoma evansi infected Wistar rats.
作者： Nathieli B. Bottari , Matheus D. Baldissera , Camila B. Oliveira , Thiago Duarte , Marta M.M.F. Duarte
DOI: 10.1016/J.MICPATH.2014.06.004
关键词: Group B 、 Endocrinology 、 Immune system 、 Immunology 、 Parasitemia 、 Internal medicine 、 Trypanosoma 、 Cytokine 、 Biology 、 Zinc 、 Adenosine deaminase 、 Trypanosoma evansi
摘要: The aim of this study was to evaluate the effect zinc supplementation on ecto-adenosine deaminase activity (E-ADA), seric levels and cytokines (TNF-α, IL-1, IL-6, IL -10) rats experimentally infected by Trypanosoma evansi. Four groups with 10 each were used as negative controls (groups A B), while animals from C D intraperitoneally 0.1 mL cryopreserved blood containing 1.4 × 10(4) trypanosomes. Animals B received two doses Zinc (Zn) at 5 mg kg(-1), subcutaneously, 2nd 7th day post-infection (PI). Blood samples collected days 5 (n = 5) 15 PI (n = 5). Zn able increase rat's longevity reduce their parasitemia. It observed that increased under supplementation. supplemented showed changes in E-ADA cytokine (P < 0.05). healthy (Group activity, well reduced concentration cytokines. Infected Finally, we led a modulation cytokine's level T. evansi, activity.
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