Adenosine deaminase. A pluridisciplinary enzyme

摘要: Adenosine deaminase is an enzyme that actively participates in the metabolism of adenine nucleotides. It catalyzes irreversible hydrolytic deamination deoxyadenosine and adenosine with production deoxyinosine inosine respectively ammonia. This thus plays important role lympho-monocyte maturation activation. The increase its activity different biological fluids (pleural, pericardial, peritoneal, intra-articular cerebrospinal fluids) has been used as a rapid diagnostic test tuberculosis infection. In human immunodeficiency virus infection, it was verified enzymatic progressively increases serum blood cells, accompanying natural evolution disease. physiopathological mechanism not definitely established but CD4+ lymphocytes macrophages are pointed to being accountable for enzyme's activity. For this reason, could be marker cellular immune response. study cells elucidated diagnosis severe combined (due congenital lack enzyme) 30 50% cases. One type hemolytic anemia due exaggerated red cells.