Evaluation of cerebrospinal fluid adenosine deaminase activity in HIV-seropositive subjects and its association with lactate dehydrogenase and protein levels

作者: F.V. Pinheiro , V.C. Pimentel , R.N. Moresco , M.B. Moretto

DOI: 10.1016/J.BIOPHA.2009.06.011

关键词:

摘要: The purpose of this study was to investigate the role ADA as additional marker HIV infection well its association with other biochemical markers. This included 55 patients, 26 being diagnosed positive and 29 patients negative. Glucose, total protein, lactate dehydrogenase, adenosine deaminase (ADA) activity were measured on cerebrospinal fluid (CSF). CSF statistically different in HIV-seropositive subjects compared HIV-negative subjects. sensitivity specificity 50 82.76%, respectively. positively correlated dehydrogenase protein it negatively glucose levels. determination could add information about inflammatory processes infection.

参考文章(29)
J G da Cunha, Adenosine deaminase. A pluridisciplinary enzyme Acta Médica Portuguesa. ,vol. 4, pp. 315- ,(1991) , 10.20344/AMP.3373
Hans Ulrich Bergmeyer, Methods of Enzymatic Analysis ,(1963)
S. Gartner, HIV Infection and Dementia Science. ,vol. 287, pp. 602- 604 ,(2000) , 10.1126/SCIENCE.287.5453.602
J P Ungerer, H M Oosthuizen, S H Bissbort, W J Vermaak, Serum adenosine deaminase: isoenzymes and diagnostic application. Clinical Chemistry. ,vol. 38, pp. 1322- 1326 ,(1992) , 10.1093/CLINCHEM/38.7.1322
W. Fu, B. E. Sanders-Beer, K. S. Katz, D. R. Maglott, K. D. Pruitt, R. G. Ptak, Human immunodeficiency virus type 1, human protein interaction database at NCBI. Nucleic Acids Research. ,vol. 37, pp. 417- 422 ,(2009) , 10.1093/NAR/GKN708
R.M. Segura, C. Pascual, I. Ocaña, J.M. Martínez-Vázquez, E. Ribera, I. Ruiz, M.D. Pelegrí, Adenosine deaminase in body fluids: A useful diagnostic tool in tuberculosis Clinical Biochemistry. ,vol. 22, pp. 141- 148 ,(1989) , 10.1016/S0009-9120(89)80013-X
Seetharamaiah Chittiprol, P. Satishchandra, R.S. Bhimasenarao, G.R. Rangaswamy, S.V. Sureshbabu, D.K. Subbakrishna, K.S. Satish, Anita Desai, V. Ravi, K. Taranath Shetty, Plasma adenosine deaminase activity among HIV1 Clade C seropositives: Relation to CD4 T cell population and antiretroviral therapy Clinica Chimica Acta. ,vol. 377, pp. 133- 137 ,(2007) , 10.1016/J.CCA.2006.09.006
J. Pedro-Botet, J. C. Soriano, S. Tomás, R. Miralles, J. Rubiés-Prat, Adenosine deaminase in cerebrospinal fluid of cerebral toxoplasmosis in AIDS. Infection. ,vol. 19, pp. 13- 13 ,(1991) , 10.1007/BF01643749
Luisa Sorli, Eloisa Tellez, Delia Taverner, Hernando Knobel, Meningitis aséptica con ADA elevado tras interrupción del tratamiento antirretroviral Enfermedades Infecciosas y Microbiología Clínica. ,vol. 24, pp. 138- 139 ,(2006) , 10.1157/13085025