Facile synthesis of cyanofurans via Michael-addition/cyclization of ene–yne–ketones with trimethylsilyl cyanide

作者: Yue Yu , Yang Chen , Wanqing Wu , Huanfeng Jiang

DOI: 10.1039/C6CC08320J

关键词: ChemistryOrganic chemistryTrimethylsilyl cyanideEne reactionMichael reaction

摘要: We have developed a Michael-addition/cyclization procedure between ene–yne–ketones and TMSCN under metal-free conditions. A wide range of cyanofurans was delivered in high yields, which could be further transformed to series furo-furanimines, furo-pyridazines or carboxamido-furans. In addition, deuterium-labeling experiments been conducted clarify the reaction pathway.

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