作者: Yue Yu , Yang Chen , Wanqing Wu , Huanfeng Jiang
DOI: 10.1039/C6CC08320J
关键词: Chemistry 、 Organic chemistry 、 Trimethylsilyl cyanide 、 Ene reaction 、 Michael reaction
摘要: We have developed a Michael-addition/cyclization procedure between ene–yne–ketones and TMSCN under metal-free conditions. A wide range of cyanofurans was delivered in high yields, which could be further transformed to series furo-furanimines, furo-pyridazines or carboxamido-furans. In addition, deuterium-labeling experiments been conducted clarify the reaction pathway.