Reciprocal Interactions of Mitochondria and the Neuroimmunoendocrine System in Neurodegenerative Disorders: An Important Role for Melatonin Regulation.

摘要: Structural and functional alterations of mitochondria are intimately linked to a wide array medical conditions. Many factors involved in the regulation mitochondrial function, including cytokines, chaperones, chemokines, neurosteroids, ubiquitins. The role diffusely located cells neuroendocrine system, biogenic amines peptide hormones, management as well altered function these is an area intense investigation. current article looks at interactions among neuronal-glia, immune endocrine systems, namely diffuse neuroimmunoendocrine system (DNIES), how DNIES interacts with function. Whilst changes can impact on local systemic alter component systems their interactions. This has etiological, course treatment implications for range conditions, neurodegenerative disorders. Available data melatonin interactions, cellular levels, reviewed, directions future research indicated.