Neuroimaging of Dementia with Lewy Bodies

作者: Haruo Hanyu

DOI: 10.1007/978-4-431-55133-1_12

关键词: Occipital lobeDementiaAtrophyDementia with Lewy bodiesDopamine transporterNeuroimagingREM sleep behavior disorderMedicineMagnetic resonance imagingPathology

摘要: Dementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia following Alzheimer’s disease (AD). Despite development consensus diagnostic criteria, differentiating DLB from other types dementia, such as AD, can be difficult. Several imaging studies are currently underway to differentiate dementia. Magnetic resonance shows preservation medial temporal lobe structure and predominant atrophy subcortical structures, including substantia innominata dorsal midbrain, compared AD. Decreased perfusion in occipital relatively increased deep gray matter (striatum thalamus) on single photon emission CT (SPECT) shown characteristic features DLB. MIBG myocardial scintigraphy provides a higher sensitivity specificity for diagnosing probable AD than SPECT. Dopamine transporter imaging, an available technique Japan since 2014, good accuracy The international criteria (2005) incorporate abnormal dopamine supportive feature. As idiopathic REM sleep behavior disorder (iRBD) considered prodromal stage alpha-synucleinopathies, above findings observed some patients iRBD. This review summarizes applications neuroimaging

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