Biofunctional cpg or oligo-/polynucleotide and toxin or enterotoxin containing composition

摘要: A bifunctional composition comprising an intracellularly effective immunomodulating nucleic acid component containing at least one immunostimulatory, immunoinhibitory or motif and selected from a mononucleotide, dinucleotide, oligonucleotide polynucleotide with either natural phosphodiester backbone modified backbone, optionally in combination specific antigen, association protein binding to receptors on mammalian cell surfaces the group consisting of cholera toxin (CT), subunit B CT (CTB), Escherichia coli heat labile enterotoxin (LT), LT (LTB), proteins derivatives that react antiserum LT, bind GM1 ganglioside, ADP-ribosylates acceptor protein, give rise accumulation cyclic AMP target cells, antibodies other which after surface can be internalized into cell, is described. The useful for treatment tumors, infections, graft rejections, immunosuppressive states, autoimmune diseases allergies, further antigen it immunoprophylaxis, immunotherapy induction tolerance, ex vivo antigen-presenting subsequent infusion mammal vaccination purposes.