Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response

作者: FuGang Zhu , Yukui Li , Daqing Wang , Dong Yu , Lakshmi Bhagat

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摘要: The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand agonist. may the prevention treatment cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin allergy, asthma disease caused by pathogen.

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