Effects of Glucagon on Amino Acid Transport and Utilization in the Perfused Rat Liver
作者： L.E. Mallette , J.H. Exton , C.R. Park
DOI: 10.1016/S0021-9258(18)63619-1
关键词: Biochemistry 、 Endocrinology 、 Glycine 、 Valine 、 Alanine 、 Amino acid 、 Leucine 、 Chemistry 、 Phenylalanine 、 Internal medicine 、 Amino acid synthesis 、 Isoleucine
摘要: The effects of glucagon on the output amino acids by isolated rat liver perfused with recirculating medium were to decrease that glycine, glutamate, and phenylalanine; increase greatly leucine, isoleucine, valine, tyrosine; slightly lysine histidine. In livers nonrecirculating containing at concentrations found in plasma from normal rats, produced changes intracellular extracellular which suggested a stimulation (a) utilization alanine, (b) production valine; (c) inward transport and, other experiments, nonmetabolizable acids, α-aminoisobutyrate 1-aminocyclopentane carboxylic acid. acid caused resembled those diabetic animals.
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