Dose-dependent reversal of acute murine colchicine poisoning by goat colchicine-specific Fab fragments.
作者： A SABOURAUD , M URTIZBEREA , M GRANDGEORGE , P GATTEL , M MAKULA
DOI: 10.1016/0300-483X(91)90015-S
关键词: Stereochemistry 、 Medicine 、 Alkaloid 、 Ratón 、 Antidote 、 Papain 、 Colchicine 、 Poison control 、 Antibody 、 Pharmacology 、 Toxicity
摘要: Abstract The use of colchicine-specific Fab fragments is interest in human poisoning. In the present study, we show efficacy reversing colchicine toxicity mice. High affinity antibodies (Ka = 2 × 1010 M−1) against were raised goats; purified by DEAE chromatography after papain hydrolysis IgG. Mice intoxicated with a 100% lethal dose (3.8 mg/kg). When half molar (M/2) relation to was intravenously and intraperitoneally administered 90 min infusion using multiple dosage schedule, 80% Fab-treated mice survived compared control group which did not receive (P
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