A direct, stereoselective synthesis of optically active conhydrines
作者： Gabor Fodor , Eberhard Bauerschmidt
关键词: Levorotatory 、 Optically active 、 Chemistry 、 Stereoselectivity 、 Epimer 、 Stereochemistry 、 Ketone 、 Conhydrine 、 Base (chemistry)
摘要: 2-Pyridylethylcarbinol (I) has been resolved and the antipodes hydrogenated as free bases. The (+) form gave conhydrine (II) while (-) afforded levorotatory base stereoselectively with minor contamination of other epimer. Hydrogenation racemic I well 2-pyridyl ethyl ketone in acid solution led formerly to mixture both racemates.
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