A school outbreak of Norwalk-like virus: evidence for airborne transmission.
作者： P. J. MARKS , I. B. VIPOND , F. M. REGAN , K. WEDGWOOD , R. E. FEY
DOI: 10.1017/S0950268803008689
关键词: Vomiting 、 Polymerase chain reaction 、 Outbreak 、 Virology 、 Virus 、 Airborne transmission 、 Caliciviridae 、 Epidemiology 、 Viral disease 、 Medicine
摘要: An outbreak of gastroenteritis affected a school attended by children aged 4-11 years. Epidemiological features suggested this was due to Norwalk-like virus (NLV) and confirmed polymerase chain reaction (PCR). Nucleotide sequence analysis the PCR amplicons revealed identical strains in all five positive stool samples. Pupils were significantly more likely become ill following an episode vomiting within their classroom (adjusted odds ratio 4.1, 95% CI 1.8-9.3). The times from exposure illness consistent with direct infection aerosolized viral particles where high. Cleaning quaternary ammonium preparations made no impact on course outbreak. However, stopped after closed for 4 days cleaned using chlorine-based agents. This study confirms importance transmission NLV provides evidence that occurs.
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