Stigma Variations: Observations on Suppressor T Cells and Leprosy

摘要: Few areas of immunology have been so controversial as that suppressor T cells. Studies cell clones derived from patients with infectious diseases, including leprosy, and allergies allowed the delineation functional human subsets. Both CD4 CD8 cells can be discriminated into subsets are differentiated by their functions patterns lymphokines. Type 1 reactive lepromin PPD produce IFN-gamma IL-2 predominantly, while 2 clones, specific for tetanus toxoid, IL-4 IL-5. cytotoxic lymphocytes predominantly IL-2. immunologically unresponsive lepromatous leprosy antigen-specific, cells, HLA-DQ restricted, IL-4, were designated Several models peripheral tolerance based on distinct discussed. Previous suppression in mouse reciprocal relationship between humoral cell-mediated immunity general reinterpreted light such subset interactions.