Condensin I associates with structural and gene regulatory regions in vertebrate chromosomes.
作者： Ji Hun Kim , Tao Zhang , Nicholas C. Wong , Nadia Davidson , Jovana Maksimovic
DOI: 10.1038/NCOMMS3537
关键词: Heterochromatin 、 Condensin 、 Chromosome segregation 、 Meiosis 、 Centromere 、 SMC protein 、 Condensin complex 、 Mitosis 、 Biology 、 Genetics
摘要: The condensin complex is essential for correct packaging and segregation of chromosomes during mitosis meiosis in all eukaryotes. To date, the genome-wide location nature condensin-binding sites have remained elusive vertebrates. Here we report map I chicken DT40 cells. Unexpectedly, find that binds predominantly to promoter sequences mitotic We also a striking enrichment at both centromeres telomeres, highlighting importance chromosome segregation. Taken together, results show largely absent from heterochromatic regions. This binding on genome reveals patterns distribution are conserved prokaryotes, through yeasts Thus three kingdoms life, enriched promoters actively transcribed genes loci important
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