Synthesis, spectroscopic characterization and structural investigation of a new charge transfer complex of 2,6-diaminopyridine with 4-nitrophenylacetic acid: Antimicrobial, DNA binding/cleavage and antioxidant studies.
作者： Venkatesan Murugesan , Munusamy Saravanabhavan , Marimuthu Sekar
DOI: 10.1016/J.SAA.2015.03.083
关键词: Thermal stability 、 DNA 、 Combinatorial chemistry 、 Crystal structure 、 Chemistry 、 Hydrogen bond 、 Organic chemistry 、 Charge-transfer complex 、 Acceptor 、 Molecule 、 Intercalation (chemistry)
摘要: A new hydrogen-bonded charge-transfer complex (CT) formed by the reaction between donor, 2,6-diaminopyridine and acceptor, 4-nitrophenylacetic acid in methanol at room temperature. The crystal was characterized elemental analysis, IR, NMR spectroscopic studies thermal studies. analysis of CT complex, obtained data revealed that formation 1:1 ratio proposed. Infrared confirm chemical constituents molecular structure synthesized crystal. high stability is due to frame work through H-bonding interactions. Structural investigation indicates cation anion are linked strong N(+)-H⋯O(-) type hydrogen bond. bonded charge transfer screened for its pharmacology, such as antimicrobial, DNA binding/cleavage antioxidant antibacterial antifungal activity against various bacterial fungal species, which shows good antimicrobial activity. binding results indicated compound could interact with intercalation. It should have weak moderate capacity scavenging DPPH.
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