Voxel-Based Morphometry of Disproportionate Cerebrospinal Fluid Space Distribution for the Differential Diagnosis of Idiopathic Normal Pressure Hydrocephalus

作者: Fumio Yamashita , Makoto Sasaki , Makoto Saito , Etsuro Mori , Atsushi Kawaguchi

DOI: 10.1111/JON.12049

关键词: Distribution (pharmacology)Healthy control(Idiopathic) normal pressure hydrocephalusDifferential diagnosisPathologyVoxelCardiologyVoxel-based morphometryParkinson's diseaseInternal medicineCerebrospinal fluidMedicine

摘要: OBJECTIVE To determine whether voxel-based morphometry of the cerebrospinal fluid (CSF) space can accurately differentiate iNPH from other related neurological disorders. METHODS Nineteen patients with surgically proven and 24 Alzheimer's disease (AD), 18 Parkinson's (PD), 14 healthy elderlies were examined. Regions interest (ROIs) in ventricular/sylvian (VS) high convexity/midline (HCM) areas used VBM, differences CSF volume within these ROIs among 4 groups examined. RESULTS The relative VS-ROI group (.64) was significantly higher than that AD, PD, control (.26, .29, .17, respectively; P < .001), whereas HCM-ROI reduced (.10) (.17, .16, respectively) (P .001). Furthermore, ratio 2 (VS/HCM) markedly (6.87) (1.65, 1.74, .97, sensitivity specificity .89 1.00, respectively. CONCLUSIONS The VBM-based analysis detect disproportionate changes those AD or PD accurately.

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