A quantitative index of intracranial cerebrospinal fluid distribution in normal pressure hydrocephalus using an MRI-based processing technique.

摘要: Our purpose was to quantify the intracranial cerebrospinal fluid (CSF) volume components using an original MRI-based segmentation technique and investigate whether a CSF index is useful for diagnosis of normal pressure hydrocephalus (NPH). We studied 59 subjects: 16 patients with NPH, 14 young 13 elderly volunteers, cerebrovascular disease. Images were acquired on 1.5-T system, 3D-fast asymmetrical spin- echo (FASE) method. A region-growing method (RGM) used extract spaces from FASE images. Ventricular (VV) (ICV) measured, VV/ICV ratio calculated. Mean VV higher in NPH group than other groups, differences statistically significant, whereas mean ICV value not significantly increased. Of group, had ratios above 30 %. In contrast, no subject groups conclude that these parameters, especially ratio, are NPH.