Antimalarial drugs and pregnancy: safety, pharmacokinetics, and pharmacovigilance
作者： Stephen A Ward , Esperanca JP Sevene , Ian M Hastings , François Nosten , Rose McGready
DOI: 10.1016/S1473-3099(07)70025-7
关键词: Pharmacovigilance 、 Population 、 Pregnancy 、 Reproductive toxicology 、 Drug treatment 、 Intensive care medicine 、 Pharmacology 、 Drug 、 Drug disposition 、 Pharmacokinetics 、 Medicine
摘要: Before a recommendation for antimalarial drug use in pregnancy is made, it essential that we understand the potential risks involved and have mechanisms place to monitor risk during treatment. This requires data on disposition toxicological liabilities developing fetus mother. In most cases this information not available. We review reproductive toxicology of main classes or under development. Preclinical are presented if appropriate, but as human experience overrides such data, instances which preclinical studies do correlate with reviewed only briefly. Additionally, highlight lack appropriate suggest can be used capture after treatment pregnancy.
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