Hyaluronan, CD44 and fibronectin in rabbit corneal epithelial wound healing.

摘要: Changes in hyaluronan (HA) concentration and stainability were investigated the rabbit cornea after wounds made by exposure to n-heptanol. The HA increased gradually until day 14 wounding, then decreased. returned normal level 56 days wounding. In control cornea, staining was observed epithelium stroma. intensity of stroma 3 when had completely covered defect. At 28, thickness corneal level, also However, still strong. decreased parallel experiments, immunostaining for CD44, an receptor, fibronectin (FN) carried out same model. both CD44 FN synchronistic with during early stages These events suggest that HA, cooperatively play important roles epithelial wound healing.