DNA DAMAGE BY MERCURY COMPOUNDS: AN OVERVIEW

摘要: HgCl2-induced DNA damage has many similarities to those caused by X-rays; however, the single strand breaks induced HgCl2 are not readily repaired, in contrast X-rays. also been shown inhibit repair of X-ray breaks. induce frank breaks, alkali-labile sites. was assessed disappearance lesions as evaluated alkaline elution studies and CsCl density gradient analysis. Similar X-rays, cause formation superoxide radicals depletion reduced glutathione intact cells. The binding mercury be very tight since it resisted extraction with high salt chelating agents. depended upon polynucleotide structure DNA, because degradation mononucleotides resulted release bound 203Hg. Methyl-HgCl compared for induction cultured rat glial cells, human nerve cells (HTB), or fibroblasts. much more effective at inducing plating efficiency than These other findings suggest that potent cellular toxicity methyl-HgCl involve damage. Although methyl-HgCl2 is producing cytotoxicity fibroblasts, toxic fibroblasts HgCl2. lack extensive mercury-induced may, part, explain carcinogenicity these agents, despite their potential